av H Sonesson · 2017 — verkar bli mindre med anti-pHH3 än vid räkning av mitoser, som är mer Ki67/MIB-1, mitosin, survivin, pHH3 and DNA topoisomerase Iiα in human anaplastic

Anti‐topoisomerase I auto‐antibodies (ATA) in systemic sclerosis (SSc) are associated with diffuse skin involvement and interstitial lung fibrosis. Thus far, however, the relations between the ATA response and disease course have not yet been fully evaluated. Objectives.

Find out information about anti-topoisomerase I antibody. protein produced by the immune system in response to the presence in the body of antigens: foreign proteins or polysaccharides such as bacteria, bacterial Explanation of anti-topoisomerase I antibody Anti-Topoisomerase II alpha + Topoisomerase II beta antibody [EPR5377] browse more products. Anti-alpha 1 Fetoprotein antibody [EP1016Y] | ab52940; Response to Anti-Topoisomerase II Agents Ian G. Cowell * and Caroline A. Austin Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, Tyne and Wear NE2 4HH, UK; E-Mail: caroline.austin@ncl.ac.uk * Author to whom correspondence should be addressed; E-Mail: ian.cowell@ncl.ac.uk; Type II DNA topoisomerases have the ability to generate a transient DNA double-strand break through which a second duplex can be passed; an activity essential for DNA decatenation and unknotting. Topoisomerase poisons stabilize the normally transient topoisomerase-induced DSBs and are potent and widely used anticancer drugs. However, their use is associated with therapy-related secondary Sep 18, 2017 Significance of Anti-Topoisomerase I Antibodies in Routine Clinical Testing. Anne E Tebo1, Robert L. Schmidt2 and Tracy M. Frech3, Antitopoisomerase I antibodies (ATA) and anticentromere antibodies (ACA) are important diagnostic markers of SSc. Each of these autoantibodies can be found in Anti-Topoisomerase I-DNA Covalent Complexes Antibody, clone 1.1A is an antibody against Topoisomerase I-DNA Covalent Complexes for use in Anti-topoisomerase I (anti-Scl-70) antibodies in patients with systemic lupus erythematosus. Hélène A Elicha Gussin, Georghe P. Ignat, John Varga, Marius Western blot analysis of whole cell lysates probed with topoisomerase II alpha antibody followed by detection with Goat anti Mouse HRP conjugated (1/10,000, This is an antibody to a the enzyme topoisomerase I. Anti-Scl 70 may be found in the following conditions: pre-scleroderma; diffuse cutaneous systemic sclerosis 400 products Listed below are anti-Topoisomerase II antibodies from multiple suppliers.

Ontology: Topoisomerase-1 antibody (C0700437) Derived from the NIH UMLS (Unified Medical Language System) All lanes : Anti-Topoisomerase II alpha antibody [EP1102Y] (ab52934) at 1/1000 dilution Lane 1 : HeLa (human cervix adenocarcinoma) whole cell lysate Lane 2 : Jurkat (human acute T cell leukemia) whole cell lysate Lane 3 : Neuro-2a (mouse neuroblastoma) whole cell lysate Lane 4 : Human breast cancer lysate Lane 5 : Mouse thymus lysate The presence of anti-SCL-70 (anti-topoisomerase) antibodies is highly specific to the diagnosis of diffuse scleroderma, while the presence of anti-centromere antibodies is highly specific to the diagnosis of limited scleroderma. The presence of Scl-70 antibodies (also referred to as topoisomerase I, topo-I or ATA) is considered diagnostic for systemic sclerosis (SSc). Scl-70 antibodies alone are detected in about 20 percent of SSc patients and are associated with the diffuse form of the disease, which may include specific organ involvement and poor prognosis. 24 antibodies to Topoisomerase I and validated for use in 7 applications (Immunohistochemistry, Western Blot, Immunoprecipitation, Flow Cytometry, ChIP assay, Immunocytochemistry, Immunofluorescence) There was a significantly positive association between anti-topoisomerase I Ab levels and MRSS and a significantly negative association with disease duration by multiple regression analysis. Our findings suggest that serum levels of anti-topoisomerase I Ab reflect the severity of skin sclerosis in patients with SSc. Anti-topoisomerase antibodies can be classified according to their immunoglobulin class (IgM, IgG or IgA). IgG-ATA is found most frequently in scleroderma, with IgA being quite common but IgM very infrequent. Pathology Topoisomerase I is an enzyme that relaxes the strain on DNA by nicking and ligating the DNA. Anti‐topoisomerase I auto‐antibodies (ATA) in systemic sclerosis (SSc) are associated with diffuse skin involvement and interstitial lung fibrosis.

- Long-term security of supply. - Animal-free production. For more information see here.

Topoisomeras II-hämmande cytostatika såsom etoposid, teniposid och antracykliner [158,. 159]. Anti-Mülleriskt Hormon (AMH) kan eventuellt

Size: 100ug/vial. Source: Rabbit Rabbit Monoclonal Topoisomerase II alpha Antibody. Validated in IP, IHC, WB and tested in Human, Mouse, Rat. Size: 100ug/vial.

Home > Topoisomerase-antibodies Topoisomerase Related Drugs Abstract OBJECTIVE: The presence of anti-DNA topoisomerase I (anti-topo I) antibody.

Antracykliner.

En för- av Trastuzumab kopplat till en topoisomeras-.
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Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA topoisomerase I antibody (anti-topo At SRUK Annual Conference 2017 anti-Topoisomerase II antibody [SQab1727] is a Recombinant Rabbit Monoclonal antibody [SQab1727] recognizes Topoisomerase II, which can be used for IHC-Formalin-fixed paraffin-embedded sections,Western blot testing with Human,Mouse samples. anti-topoisomerase I antibody: An autoantibody found in the serum of patients with progressive systemic sclerosis, silicosis, and systemic lupus erythematosus. Higher levels of the antibody correlate with worsening kidney, lung, and skin disease. Synonym: anti-scl-70 antibody See also: antibody anti-Topoisomerase II alpha Antibodies 181 Topoisomerase (DNA) II alpha 170kDa (TOP2A) Antibodies from 20 manufacturers are available on www.antibodies-online.com.

arbete i framtiden (biomarkör fibros och anti-fibrotisk antikroppsbehandling). plan var att inducera fibros genom immunisering med humant topoisomeras.
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Conclusion The results suggest that the BANK1 gene confers susceptibility to SSc in general, and specifically to the dcSSc and anti-topoisomerase I antibody

REACH- registreringsnummer: Denna produkt är en blandning. Topoisomerase II-alpha (topo II alpha) is the key target enzyme for the topoisomerase inhibitor class of anti-cancer drugs. In normal cells, topo II alpha is frekvent förekomst av inre organengagemang och karakteriseras serologiskt av antikroppar mot topoisomeras I (anti-Scl 70 antikroppar, ATA) i cellkärnor. Topoisomeras I-hämmare Topoisomeras II-hämmare huvudsakligen verka genom anti-angiogenetisk och immunmodulerande/antiinflammatorisk aktivitet.

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This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity and specificity. - Long-term security of supply. - Animal-free production. For more information see here.

Rabbit anti Human topoisomerase II alpha antibody recognizes the DNA topoisomerase II alpha, also known as DNA gyrase or DNA topoisomerase (ATP-hydrolyzing). TOP2A gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. The anti-Topoisomerase II alpha/TOP2A antibody (PA1127) has not been validated for cross reactivity specifically with pig tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in pig you can get your next antibody for free. Order monoclonal and polyclonal Topoisomerase I antibodies for many applications. Selected quality suppliers for anti-Topoisomerase I antibodies.